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KMID : 0350519940470041639
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Journal of Catholic Medical College
1994 Volume.47 No. 4 p.1639 ~ p.1649
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Expression of Epidermal Growth Factor Receptor and proliferative Activity in Glioma
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Abstract
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It has been suggested that glial tumorigenesis is the dynamic process, which occurs through a series of genetic alteration such a s activation of oncogenes and inactivation of tumor suppressor genes.
Epidermal growth factor receptor(EGFR) gene is amplified in 40-50% case of malignant glioma. In cases of EGFR-expressed tumor, proliferative activity may be more increased than EGFR-nonexpressed cases. But there was a denial about the
relationship
between expression of EGFR and proliferative acitivity in human malignant tumor.
The aim of this study was to determine possible relationships between expression of EGFR and proliferative activity, and to know the possibility of targeting these receptors as a new treatment of malignant glioma, and to compare proliferating
cell
nuclear antigen labelling index(PCNA LI) with Ki-67 LI.
We undertook the immunohistochemical study of the EGFR in 63 cases of human glioma, including 48 cases of malignant glioma. And then 48 cases of malignant glioma were subdivided, according to 1) positivity of EGFR immunohistochemical staining, 2)
semiquantitatively, distributed proportion of EGFR-expressed tumor cells, 3) staining intensity of EGFR-expressed tumor cells, 4) EGFR labelling factor. We compared the states of EGFR expression with proliferative activity in each subgroups.
@ES The results were as follows:
@EN 1. Expression of EGFR was detected in 1 cases(6.7%) of low grade glioma, 14 cases(63.6%) of anaplastic astrocytoma and 19 cases(73.1%) of glioblastoma multiforme. It was more frequent in malignant gliomas than low grade gliomas(P<0.01).
2. Regional heterogeneity of EGFR-expressed tumor cells was recognized, but the distributed proportion of EGFR-expressed tumor cells was more increased in glioblastoma multiforme than anaplastic astrocytoma.
3. The proliferative activity was gradually increased according to the grade of malignancy(P<0.01). Correlation of PCNA LI and Ki-67 LI was statistically significant. In each subgroup, the proliferative activity of EGFR-expressed of EGFR, the
more
increase of proliferative activity(P<0.05).
The results suggest that expression of EGFR was more common in malignant glioma than low grade glioma, and it was correlated with proliferative activity in malignant glioma. Overexpression of EGFR in glioma would be involved in malignant
transformation
and provides more growth advantage. In case, overexpression of EGFR was existed or EGFR-expressed tumor cells were diffusely distributed in malignant glioma, targeting these receptors as a new treatment may be useful for human malignant glioma.
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